Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma

被引：9
|
作者：
Thanh-Nhan Nguyen-Pham [2 ]
Im, Chang-Min [3 ]
Truc-Anh Thi Nguyen [4 ]
Lim, Mi-Seon [4 ]
Hong, Cheol Yi
Kim, Mi-Hyun
Lee, Hyun Ju
Lee, Youn-Kyung
Cho, Duck
Ahn, Jae-Sook [2 ]
Yang, Deok-Hwan [2 ]
Kim, Yeo-Kyeoung [2 ]
Chung, Ik-Joo [2 ,4 ]
Kim, Hyeoung-Joon [2 ]
Lee, Je-Jung [1 ,2 ,4 ]
机构：
[1] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Res Ctr Canc Immunotherapy, Hwasun 519763, Jeollanamdo, South Korea
[2] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol & Oncol, Hwasun 519763, Jeollanamdo, South Korea
[3] Chonnam Natl Univ, Hwasun Hosp, Dept Urol, Hwasun 519763, Jeollanamdo, South Korea
[4] Chonnam Natl Univ, Ctr Biomed Human Resources, Brain Korea Project 21, Kwangju, South Korea
来源：
LEUKEMIA RESEARCH | 2011年 / 35卷 / 09期
关键词：
Dendritic cells; Natural killer cells; Multiple myeloma; Immunotherapy; DOUBLE-STRANDED-RNA; NK CELLS; IN-VIVO; MATURATION; ACTIVATION; IL-12; REQUIRES; RECEPTOR; ABILITY; CD38;
D O I：
10.1016/j.leukres.2011.03.032
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The interaction between dendritic cells (DCs) and natural killer (NK) cells plays a key role in inducing DC maturation for subsequent T-cell priming. We investigated to generate potent DCs by stimulated with NK cells to induce myeloma-specific cytotoxic T lymphocytes (CTLs). NK cells-stimulated-DCs exhibited high expression of costimulatory molecules and high production of IL-12p70. These DCs induce high potency of Th1 polarization and exhibit a high ability to generate myeloma-specific CTLs responses. These results suggest that functionally potent DCs can be generated by stimulation with NK cells and may provide an effective source of DC-based immunotherapy in multiple myeloma. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1241 / 1247
页数：7
相关论文
共 50 条
  • [1] Induction and identification of myeloma-specific cytotoxic T cells
    Zahradova, L
    Ocadlikova, D
    Kovarova, L
    Penka, M
    Hajek, R
    Michalek, J
    [J]. EXPERIMENTAL HEMATOLOGY, 2005, 33 (07) : 97 - 98
  • [2] Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes
    Hayashi, T
    Hideshima, T
    Akiyama, M
    Rajo, N
    Richardson, P
    Chauhan, D
    Anderson, KC
    [J]. BLOOD, 2003, 102 (04) : 1435 - 1442
  • [3] Ex vivo induction of multiple myeloma-specific T-cell responses by dendritic cells stimulated by whole-tumour antigen of autologous myeloma cells
    Vasileiou, S.
    Baltadakis, I.
    Delimpasi, S.
    Karatza, M.
    Manaka, A.
    Liapis, K.
    Papageorgiou, M.
    Garofalaki, M.
    Tziotziou, E.
    Poulopoulou, Z.
    Nikolou, E.
    Bika, E.
    Apostolidis, J.
    Karakasis, D.
    Harhalakis, N.
    Bourantas, K.
    Nikiforakis, E.
    [J]. BONE MARROW TRANSPLANTATION, 2011, 46 : S313 - S313
  • [4] The induction of multiple myeloma-specific cytotoxic T lymphocyte stimulation with purified myeloma cell lysate pulsed dendritic cells.
    Lee, JJ
    Park, MS
    Nam, JH
    Choi, BH
    Song, WH
    Kim, YK
    Byun, JR
    Lee, IK
    Chung, LJ
    Kim, HJ
    [J]. BLOOD, 2003, 102 (11) : 387B - 387B
  • [5] Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes.
    Hayashi, T
    Hideshima, T
    Akiyama, M
    Raje, N
    Chauhan, D
    Anderson, KC
    [J]. BLOOD, 2002, 100 (11) : 400A - 400A
  • [6] Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA
    Milazzo, C
    Reichardt, VL
    Müller, MR
    Grünebach, F
    Brossart, P
    [J]. BLOOD, 2003, 101 (03) : 977 - 982
  • [7] IN VITRO ACTIVATION OF MYELOMA-SPECIFIC CYTOTOXIC T CELLS BY MUC1 PULSED DENDRITIC CELLS
    Kryukov, F.
    Zahradova, L.
    Ocadlikova, D.
    Kovarova, L.
    Matejkova, E.
    Hajek, R.
    Michalek, J.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 29 - 29
  • [8] Dendritic cells loaded with myeloma cells pretreated with a combination of JS']JSI-124 and bortezomib generate potent myeloma-specific cytotoxic T lymphocytes in vitro
    Jung, Sung-Hoon
    Lee, Youn-Kyung
    Lee, Hyun-Ju
    Choi, Nu-Ri
    Manh-Cuong Vo
    My-Dung Hoang
    Lim, Mi-Seon
    Thanh-Nhan Nguyen-Pham
    Kim, Hyeoung-Joon
    Lee, Je-Jung
    [J]. EXPERIMENTAL HEMATOLOGY, 2014, 42 (04) : 274 - 281
  • [9] Induction of multiple myeloma-specific cytotoxic T lymphocyte stimulation by dendritic cell pulsing with purified and optimized myeloma cell lysates
    Lee, Je-Jung
    Choi, Bo-Hwa
    Kang, Hyun-Kyu
    Park, Myong-Suk
    Park, Jung-Sun
    Kim, Sang-Ki
    Pham, Thanh-Nhan Nguyen
    Cho, Duck
    Nam, Jong-Hee
    Kim, Young-Jin
    Rhee, Joon-Haeng
    Yang, Deok-Hwan
    Kim, Yeo-Kyeoung
    Kim, Hyeoung-Joon
    Chung, Ik-Joo
    [J]. LEUKEMIA & LYMPHOMA, 2007, 48 (10) : 2022 - 2031
  • [10] Induction of myeloma-specific cytotoxic T lymphocytes ex vivo by CD40-activated B cells loaded with myeloma tumor antigens
    Sang-Ki Kim
    Thanh-Nhan Nguyen Pham
    Tuyet Minh Nguyen Hoang
    Hyun-Kyu Kang
    Chun-Ji Jin
    Jong-Hee Nam
    Sang-Young Chung
    So-Jin-Na Choi
    Deok-Hwan Yang
    Yeo-Kyeoung Kim
    Ik-Joo Chung
    Hyeoung-Joon Kim
    Je-Jung Lee
    [J]. Annals of Hematology, 2009, 88 : 1113 - 1123
12345