miR-1303 promotes the proliferation, migration and invasion of prostate cancer cells through regulating the Wnt/β-catenin pathway by targeting DKK3

被引:21
|
作者
Liu, Bo [1 ]
Zhou, Weidong [1 ]
Jiang, Huiyang [1 ]
Xiang, Zhendong [1 ]
Wang, Lei [1 ,2 ]
机构
[1] Tongji Univ Med, Tongji Hosp, Dept Urol, Shanghai 200065, Peoples R China
[2] Ningbo 7 Hosp, Dept Urol, 718 South Second West Rd,Luotuo St, Ningbo 315202, Zhejiang, Peoples R China
关键词
microRNA-1303; dickkopf Wnt signaling pathway inhibitor 3; Wnt/beta-catenin pathway; prostate cancer; GENE; MANAGEMENT; THERAPY;
D O I
10.3892/etm.2019.8120
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
MicroRNA-1303 (miR-1303) is involved in the tumorigenesis and progression of several cancers, and yet the role of miR-1303 in prostate cancer (PCa) and its underlying mechanism are unknown. To explore this issue, the present study aimed to use PCa tissues, cell lines and a PCa-engrafted mouse model to determine the expression and roles of miR-1303 in PCa. Furthermore, a series of experiments were conducted to explore the underlying mechanisms of action of miR-1303 in PCa cells. miR-1303 was demonstrated to be highly expressed in PCa tissues and cell lines. The level of miR-1303 expression was closely associated with higher Gleason scores and a more developed tumor stage in patients with PCa, and patients with higher levels of miR-1303 displayed a reduced overall survival rate. miR-1303 overexpression promoted the proliferation, migration and invasion of PCa cells. In vivo experiments showed that miR-1303 inhibition suppressed the growth of PCa tumors in mice. Additionally, dickkopf Wnt signaling pathway inhibitor 3 (DKK3) was identified as a target of miR-1303. Knockdown of miR-1303 suppressed the proliferation, migration and invasion of PCa cells, increased DKK3 expression, and inhibited the activity of the Wnt/beta-catenin pathway. In conclusion, miR-1303 may promote proliferation, migration and invasion of PCa cells through activating the Wnt/beta-catenin pathway by regulating DKK3 expression. These results indicated that miR-1303 may be considered as a potential biomarker for PCa treatment.
引用
收藏
页码:4747 / 4757
页数:11
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