Umbilical cord blood: biology and transplantation

被引：2
|
作者：
Doan, Phuong L. [2 ]
Chao, Nelson J. [1 ,2 ]
机构：
[1] Duke Univ, Div Cellular Therapy, BMT, Durham, NC 27710 USA
[2] Duke Univ, Div Cellular Therapy, Dept Med, Med Ctr, Durham, NC 27710 USA
来源：
EXPERT REVIEW OF HEMATOLOGY | 2009年 / 2卷 / 02期
关键词：
cord blood; ex vivo stem cell expansion; hematopoietic stem cell; regenerative medicine; transplantation; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; UNRELATED DONORS; SELF-RENEWAL; HEMATOPOIETIC PROGENITORS; CD34(+) CELLS; MODULATES DIFFERENTIATION; MYOCARDIAL-INFARCTION; VENTRICULAR-FUNCTION; PERIPHERAL-BLOOD;
D O I：
10.1586/EHM.09.9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Umbilical cord blood transplantation is becoming an acceptable alternative source of hematopoietic stem cells for patients with malignant diseases. Cord blood differs from bone marrow and peripheral blood progenitors in its immune tolerance and kinetics of engraftment. In this article, we will review the biology of cord blood stem cells and clinical studies of cord blood transplants in pediatric and adult populations. We will also discuss potential uses of cord blood stem cells in regenerative medicine and novel methods for ex vivo expansion of hematopoietic stem cells. As we learn more about cord blood transplants, there is the potential to overcome the limitations of cord blood transplants so that they can become more widely available.
引用
收藏
页码：197 / 208
页数：12
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