Pseudoprogression and Treatment Effect

被引：19
|
作者：
Jahangiri, Arman [1 ]
Aghi, Manish K. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
来源：
NEUROSURGERY CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 02期
关键词：
Glioblastoma; Recurrence; Angiogenesis; Imaging; Progression; ENDOTHELIAL GROWTH-FACTOR; HIGH-GRADE GLIOMAS; RECURRENT MALIGNANT GLIOMAS; CEREBRAL RADIATION NECROSIS; DIFFUSION-WEIGHTED MRI; CENTRAL-NERVOUS-SYSTEM; BRAIN-TUMOR; ADJUVANT TEMOZOLOMIDE; FOLLOW-UP; PHASE-II;
D O I：
10.1016/j.nec.2012.01.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The standard of care for newly diagnosed malignant glioblastoma entails postoperative radiotherapy and adjuvant chemotherapy with temozolomide. There has been an increase in the incidence of enhancing and progressive lesions seen on magnetic resonance imaging (MRI) following treatment. Conventional MRI with gadolinium contrast is unable to distinguish between the effects of treatment and actual tumor recurrence. New modalities have provided additional information for distinguishing treatment effects from tumor progression but are not 100% sensitive or specific in diagnosing progression. Novel radiographic or nonradiographic biomarkers with sensitivity and specificity verified in large randomized clinical trials are needed to detect progression.
引用
收藏
页码：277 / +
页数：13
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