New anti-malarial flavonol glycoside from hydrangeae dulcis folium

被引：29
|
作者：
Murakami, N
Mostaqul, HM
Tamura, S
Itagaki, S
Horii, T
Kobayashi, M
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 18期
关键词：
D O I：
10.1016/S0960-894X(01)00467-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2445 / 2447
页数：3
相关论文
共 50 条
  • [1] DEVELOPMENT OF BIOACTIVE FUNCTIONS IN HYDRANGEAE-DULCIS-FOLIUM - ANTIULCER, ANTIALLERGY, AND CHOLAGOIC EFFECTS OF THE EXTRACT FROM HYDRANGEAE-DULCIS-FOLIUM
    YAMAHARA, J
    MATSUDA, H
    SHIMODA, H
    ISHIKAWA, H
    KAWAMORI, S
    WARIISHI, N
    HARADA, E
    MURAKAMI, N
    YOSHIKAWA, M
    [J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1994, 114 (06): : 401 - 413
  • [2] New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium)
    Zhang, Hailong
    Matsuda, Hisashi
    Kumahara, Akira
    Ito, Yuki
    Nakamura, Seikou
    Yoshikawa, Masayuki
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (17) : 4972 - 4976
  • [3] A NEW ANTI-MALARIAL DRUG
    HOOPER, D
    [J]. NATURE, 1946, 157 (3978) : 106 - 106
  • [4] New anti-malarial compounds from database searching
    Griffith, R
    Chanphen, R
    Leach, SP
    Keller, PA
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (04) : 539 - 542
  • [5] New trends in anti-malarial agents
    Frédérich, M
    Dogné, JM
    Angenot, L
    De Mol, P
    [J]. CURRENT MEDICINAL CHEMISTRY, 2002, 9 (15) : 1435 - 1456
  • [6] PALUDRINE - A NEW ANTI-MALARIAL DRUG
    不详
    [J]. NATURE, 1945, 156 (3968) : 596 - 597
  • [7] KINETICS OF A NEW ANTI-MALARIAL, MEFLOQUINE
    DESJARDINS, RE
    PAMPLIN, CL
    BREDOW, JV
    BARRY, KG
    CANFIELD, CJ
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1979, 26 (03) : 372 - 379
  • [8] THUNBERGINOLS-A, THUNBERGINOLS-B, AND THUNBERGINOLS-F, NEW ANTIALLERGIC AND ANTIMICROBIAL PRINCIPLES FROM HYDRANGEAE DULCIS-FOLIUM
    YOSHIKAWA, M
    UCHIDA, E
    CHATANI, N
    MURAKAMI, N
    YAMAHARA, J
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (11) : 3121 - 3123
  • [9] Development of new anti-malarial drugs derived from chloroquine
    Natarajan, Jayakumar K.
    Alumasa, John N.
    Ekoue-Kovi, Kekeli A.
    Yearick, Kimberly S.
    Roepe, Paul D.
    Wolf, Christian
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (05): : 54 - 55
  • [10] Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens
    Matsuda, H
    Shimoda, H
    Yamahara, J
    Yoshikawa, M
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (03) : 215 - 220
12345