In vitro activity of tigecycline against Bacteroides species

被引:22
|
作者
Betriu, C [1 ]
Culebras, E [1 ]
Gómez, M [1 ]
Rodríguez-Avial, I [1 ]
Picazo, JJ [1 ]
机构
[1] Hosp Clin San Carlos, Dept Clin Microbiol, Madrid 28040, Spain
关键词
susceptibility; glycylcyclines; Bacteroides fragilis group;
D O I
10.1093/jac/dki197
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: To ascertain the current susceptibility patterns of members of the Bacteroides fragilis group in our hospital and to assess the in vitro activity of tigecycline against these organisms. Methods: A total of 400 non-duplicate clinical isolates of the B. fragilis group collected from 2000 to 2002 were studied. Susceptibility testing was performed according to the reference agar dilution method described by the NCCLS. The following antimicrobials were tested: tigecycline, clindamycin, metronidazole, chloramphenicol, cefoxitin, imipenem, amoxicillin-clavulanate and piperacillin-tazobactam. Results: All strains were susceptible to metronidazole and chloramphenicol. For clindamycin and cefoxitin, the overall susceptibility rates were 59.5% and 83%, respectively. lmipenem and piperacillin-tazobactam were the most active beta-lactam agents tested. Tigecycline inhibited 89.8% of the strains at a concentration of 8 mg/L with an MIC range of <= 0.01 to > 16 mg/L. By comparing the MIC50 and MIC90 values of tigecycline among the various species of the group, B. fragilis, Bacteroides the taiotaomicron and Bacteroides vulgatus were the most susceptible (MIC50/MlC(50)s of 0.5-1/8 mg/L). Conclusions: Tigecycline exhibited activity against most isolates of the B. fragilis group tested. These results indicate that tigecycline may be useful in the treatment and prophylaxis of infections involving these organisms.
引用
收藏
页码:349 / 352
页数:4
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