Long-term impact of androgen-deprivation therapy on physical function and quality of life

BACKGROUNDThis study examined the impact of androgen-deprivation therapy (ADT) on physical function and quality of life (QOL) over 36 months. METHODSEighty-seven men with nonmetastatic prostate cancer (PC) who were starting continuous ADT and 2 control groups (86 PC controls without ADT and 86 healthy controls), matched by age and education, were enrolled. Physical function was assessed with the 6-minute walk test (6MWT), grip strength, and Timed Up and Go (TUG) test. QOL was measured with the 36-Item Short Form Health Survey of the Medical Outcomes Study. Subjects were assessed at the baseline and at 3, 6, 12, 18, 24, 30, and 36 months. Mixed effects regression models were fitted with adjustments for baseline covariates. RESULTSThe 6MWT distance improved initially and then stabilized in both control groups but remained unchanged for ADT users (P=.0030). Grip strength remained stable in control groups but declined sharply in the ADT group by 3 months and then remained stable to 36 months (P=.0041). TUG scores declined gradually in the ADT group over 36 months but were unchanged in control groups (P=.0008). Aggregate physical QOL declined in ADT users over time but remained stable in control groups (P=.0001). Aggregate mental QOL was stable in all groups. Declines seen in the first year of ADT use generally persisted over 36 months and were independent of age. CONCLUSIONSPreviously noted physical side effects over the first 12 months of ADT persisted or continued to worsen over an additional 2 years with no evidence of recovery. Exercise interventions to counteract these declines may be warranted. Cancer 2015;121:2350-2357. (c) 2015 American Cancer Society. In men with nonmetastatic prostate cancer, androgen-deprivation therapy is associated with declines in physical function (endurance, upper extremity strength, and lower extremity function) and quality of life over 1 year that persist or decline with 2 additional years of use.