Effects of a High-Fat Diet Exposure in Utero on the Metabolic Syndrome-Like Phenomenon in Mouse Offspring through Epigenetic Changes in Adipocytokine Gene Expression

被引:149
|
作者
Masuyama, Hisashi [1 ]
Hiramatsu, Yuji [1 ]
机构
[1] Okayama Univ, Dept Obstet & Gynecol, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan
关键词
INSULIN-RESISTANCE; HISTONE MODIFICATION; DIABETES-MELLITUS; MATERNAL OBESITY; SATURATED FAT; BIRTH-WEIGHT; X RECEPTOR; ADIPONECTIN; PREGNANCY; RATS;
D O I
10.1210/en.2011-2161
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The links between obesity in parents and their offspring and the role of genes and a shared environment are not completely understood. Adipocytokines such as leptin and adiponectin play important roles in glucose and lipid metabolism. Therefore, we examined whether the offspring from dams exposed to a high-fat diet during pregnancy (OH mice) exhibited hypertension, insulin resistance, and hyperlipidemia along with epigenetic changes in the expression of adipocytokine genes. OH mice were significantly heavier than the offspring of dams exposed to a control diet during pregnancy (OC mice) from 14 wk of age after an increased caloric intake from 8 wk. OH mice exhibited higher blood pressure and worse glucose tolerance than the OC mice at 24 wk. Total triglyceride and leptin levels were significantly higher and the adiponectin level was significantly lower in OH compared with OC mice at 12 wk of age. This was associated with changes in leptin and adiponectin expression in white adipose tissue. There were lower acetylation and higher methylation levels of histone H3 at lysine 9 of the promoter of adiponectin in adipose tissues of OH mice at 2 wk of age as well as at 12 and 24 wk of age compared with OC mice. In contrast, methylation of histone 4 at lysine 20 in the leptin promoter was significantly higher in OH compared with OC mice. Thus, exposure to a high-fat diet in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin, and leptin gene expression. (Endocrinology 153: 2823-2830, 2012)
引用
收藏
页码:2823 / 2830
页数:8
相关论文
共 47 条
  • [1] The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters
    Masuyama, Hisashi
    Mitsui, Takashi
    Eguchi, Takeshi
    Tamada, Shoko
    Hiramatsu, Yuji
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2016, 311 (01): : E236 - E245
  • [2] The Effects of In Utero High-Fat Diet Exposure on the Endocrine Pancreas of the Offspring
    Elsakr, Joseph M.
    Pasek, Raymond C.
    Takahashi, Diana
    Grove, Kevin L.
    Powers, Alvin C.
    Gannon, Maureen A.
    [J]. DIABETES, 2017, 66 : A574 - A575
  • [3] The Effects of High-Fat Diet Exposure In Utero on the Obesogenic and Diabetogenic Traits Through Epigenetic Changes in Adiponectin and Leptin Gene Expression for Multiple Generations in Female Mice
    Masuyama, Hisashi
    Mitsui, Takashi
    Nobumoto, Etsuko
    Hiramatsu, Yuji
    [J]. ENDOCRINOLOGY, 2015, 156 (07) : 2482 - 2491
  • [4] In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice
    Seki, Yoshinori
    Suzuki, Masako
    Guo, Xingyi
    Glenn, Alan Scott
    Vuguin, Patricia M.
    Fiallo, Ariana
    Du, Quan
    Ko, Yi-An
    Yu, Yiting
    Susztak, Katalin
    Zheng, Deyou
    Greally, John M.
    Katz, Ellen B.
    Charron, Maureen J.
    [J]. ENDOCRINOLOGY, 2017, 158 (09) : 2860 - 2872
  • [5] Effect of high-fat diet prior to pregnancy on hepatic gene expression and histology in mouse offspring
    Hori, Hiroshi
    Umezawa, Masakazu
    Uchiyama, Mariko
    Niki, Rikio
    Yanagita, Shinya
    Takeda, Ken
    [J]. JOURNAL OF PERINATAL MEDICINE, 2014, 42 (01) : 83 - 91
  • [6] Effects of a Healthy Postweaning Diet on Endocrine Defects Caused by In Utero High-Fat Diet Exposure in Mouse and Japanese Macaque
    Elsakr, Joseph
    Kievit, Paul
    Powers, Alvin C.
    Gannon, Maureen A.
    Bottino, Rita
    Takahashi, Diana L.
    [J]. DIABETES, 2018, 67
  • [7] Perinatal Exposure to Bisphenol A at Reference Dose Predisposes Offspring to Metabolic Syndrome in Adult Rats on a High-Fat Diet
    Wei, Jie
    Lin, Yi
    Li, Yuanyuan
    Ying, Chenjiang
    Chen, Jun
    Song, Liqiong
    Zhou, Zhao
    Lv, Ziquan
    Xia, Wei
    Chen, Xi
    Xu, Shunqing
    [J]. ENDOCRINOLOGY, 2011, 152 (08) : 3049 - 3061
  • [8] Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood
    Srinivasan, Malathi
    Katewa, Subhash D.
    Palaniyappan, Arivazhagan
    Pandya, Jignesh D.
    Patel, Mulchand S.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 291 (04): : E792 - E799
  • [9] Phenotypic effects to the mouse brain cortex after in utero exposure to high-fat diet: A case for quantitative proteomics
    Manousopoulou, A.
    Roumeliotis, T.
    Hawkes, C.
    Weller, R. O.
    Garbis, S. D.
    Carare, R. O.
    [J]. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2014, 40 : 20 - 20
  • [10] Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates
    Suter, Melissa
    Bocock, Philip
    Showalter, Lori
    Hu, Min
    Shope, Cynthia
    McKnight, Robert
    Grove, Kevin
    Lane, Robert
    Aagaard-Tillery, Kjersti
    [J]. FASEB JOURNAL, 2011, 25 (02): : 714 - 726