Flow injection analysis of Ciprofloxacin by terbium sensitized chemiluminescence method

A new flow injection chemiluminescence (CL) method. for the determination of Ciprofloxacin (CPLX) was described. The method was based on the weak CL reaction of Ce(IV) -SQ(3)(2-) sensitized by Tb3+ -CPLX. The relative CL intensity was linear with the concentration of CPLX in the range of 9.0 X 10(-9)- 1.0 X 10(-6) mol center dot L-1. The detection limit is 2.2 X 10(-11) mol center dot L-1. The relative standard deviation (RSD) for the determination of 5.0 X 10(-8) mol center dot L-1 CPLX is 3.0% (n = 11). The method has been successfully applied to the analysis of CPLX in tablet and capsule. An original mechanism was proposed to explain this phenomenon.