In vivo 7Li and 19F NMR studies of drugs in the brain

被引：0
|
作者：
Komoroski, RA [1 ]
机构：
[1] Univ Arkansas Med Sci, Dept Radiol, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA
[3] Univ Arkansas Med Sci, Dept Psychiat, Little Rock, AR 72205 USA
[4] Univ Arkansas Med Sci, Dept Biochem, Little Rock, AR 72205 USA
来源：
CURRENT SCIENCE | 1999年 / 76卷 / 06期
关键词：
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
For various reasons, it is advantageous to measure the concentration of a psychoactive drug in the brain in vivo. Many drugs contain the element fluorine, Using F-19 NMR spectroscopy, we have studied the psychoactive drugs trifluoperazine and fluoxetine in the brain in vivo. Using Li-7 NMR, it is possible to detect lithium ion, used to treat manic depressive illness. We have measured the concentration and distribution of lithium in both human and rat brain in vivo. Measurement of drug levels in the human brain may provide a measure of therapeutic or toxic effects, as well as insight into drug metabolism and mechanism of action.
引用
收藏
页码：789 / 793
页数：5
相关论文
共 50 条
  • [1] 7Li{19F} TEDOR NMR to observe the lithium migration in heated montmorillonite
    Bodart, Philippe R.
    Delmotte, L.
    Rigolet, S.
    Brendle, J.
    Gougeon, Regis D.
    APPLIED CLAY SCIENCE, 2018, 157 : 204 - 211
  • [2] STATES IN 19F EXCITED BY 16O(7LI,ALPHA)19F REACTION
    BISHOP, JN
    MIDDLETO.R
    BULLETIN OF THE AMERICAN PHYSICAL SOCIETY, 1969, 14 (04): : 530 - &
  • [3] Differential cross-section measurements for the 7Li(p,p0)7Li, 7Li(p,p1)7Li, 7Li(p,α0)4He, 19F(p,p0)19F, 19F(p,α0)16O and 19F(p,α1,2)16O reactions
    Paneta, V.
    Kafkarkou, A.
    Kokkoris, M.
    Lagoyannis, A.
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2012, 288 : 53 - 59
  • [4] In vivo 7Li NMR studies on shift reagent infused rats
    Ramaprasad, S
    Lindquist, DM
    Wall, PT
    JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, 1999, 34 (09): : 1839 - 1848
  • [5] In vivo 7Li NMR studies on shift reagent infused rats
    Ramaprasad, S.
    Lindquist, Diana M.
    Wall, Paul T.
    Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 1999, 34 (09): : 1839 - 1848
  • [6] Insights into the lithiation mechanism of CFx by a joint high-resolution 19F NMR, in situ TEM and 7Li NMR approach
    Zhong, Guiming
    Chen, Huixin
    Cheng, Yong
    Meng, Lingyi
    Liu, Haodong
    Liu, Zigeng
    Zheng, Guorui
    Xiang, Yuxuan
    Liu, Xiangsi
    Li, Qi
    Zhang, Qiaobao
    Yue, Hongjun
    Lu, Canzhong
    Yang, Yong
    JOURNAL OF MATERIALS CHEMISTRY A, 2019, 7 (34) : 19793 - 19799
  • [7] A priori estimates of 7Li, 15N, and 19F contents in chondrites
    E. A. Petrov
    Doklady Earth Sciences, 2006, 409 : 935 - 937
  • [8] A priori estimates of 7Li, 15N, and 19F contents in chondrites
    Petrov, E. A.
    DOKLADY EARTH SCIENCES, 2006, 409 (06) : 935 - 937
  • [9] Lithium visibility in rat brain and muscle in vivo by 7Li NMR imaging
    Komoroski, RA
    Pearce, JM
    Newton, JEO
    JOURNAL OF MAGNETIC RESONANCE, 1998, 133 (01) : 98 - 103
  • [10] Lithium Visibility in Rat Brain and Muscle in Vivo by 7Li NMR Imaging
    Department of Radiology, Univ. of Arkansas for Med. Sciences, 4301 West Markham Street, Little Rock, AR 72205, United States
    不详
    不详
    不详
    不详
    J. Magn. Reson., 1 (98-103):
12345