Quantitative Evaluation of Retinal Degeneration in Royal College of Surgeons Rats by Contrast Enhanced Ultrahigh Resolution Optical Coherence Tomography

被引：0
|
作者：
Syu, Jia-Pu [1 ]
Su, Min-Jyun [1 ]
Chen, Po-Wei [2 ]
Ke, Chang-Chih [2 ]
Chiou, Shih-Hwa [2 ]
Kuo, Wen-Chuan [1 ]
机构：
[1] Natl Yang Ming Univ, Inst Biophoton, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Dept & Inst Pharmacol, Taipei 112, Taiwan
来源：
OPHTHALMIC TECHNOLOGIES XXVIII | 2018年 / 10474卷
关键词：
spectral domain optical coherence tomography; Royal College of Surgeons rat; retinal degeneration; THERAPY RESTORES VISION; SPECTRAL-DOMAIN; RCS RAT; IN-VIVO; GENE; MUTATIONS; DYSTROPHY; MODEL;
D O I：
10.1117/12.2289610
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS rats (55 weeks), the thickness of photoreceptor layer decreased significantly as compared to young RCS rats (both 4 weeks and 5 weeks). After contrast enhancement method, this platform will be useful for the quantitative evaluation of the degree of retinal degeneration, treatment outcome after therapy, and drug screening development in the future.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Optical Coherence Tomography of Retinal Degeneration in Royal College of Surgeons Rats and Its Correlation with Morphology and Electroretinography
    Adachi, Kobu
    Takahashi, Shizuka
    Yamauchi, Kodai
    Mounai, Natsuki
    Tanabu, Reiko
    Nakazawa, Mitsuru
    [J]. PLOS ONE, 2016, 11 (09):
  • [2] Quantification of microvascular change of retinal degeneration in Royal College of Surgeons rats using high-resolution spectral domain optical coherence tomography angiography
    Zhang, Zhen-Jie
    Wu, You-Ren
    Chien, Yueh
    Chen, Yang
    Chiou, Shih-Hwa
    Chen, Shih-Jen
    Syu, Jia-Pu
    Kuo, Wen-Chuan
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2023, 28 (10)
  • [3] Long-term Characterization of Retinal Degeneration in Royal College of Surgeons Rats Using Spectral-Domain Optical Coherence Tomography
    Ryals, Renee C.
    Andrews, Michael D.
    Datta, Shreya
    Coyner, Aaron S.
    Fischer, Cody M.
    Wen, Yuquan
    Pennesi, Mark E.
    McGill, Trevor J.
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (03) : 1378 - 1386
  • [4] Ultrahigh resolution optical coherence tomography for enhanced visualization of retinal pathology
    Ko, T
    Drexler, W
    Paunescu, LA
    Hartl, I
    Ghanta, R
    Schuman, J
    Fujimoto, J
    [J]. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VII, 2003, 4956 : 55 - 58
  • [5] Quantitative evaluation of retinal degeneration in rats induced with MNU using optical coherence tomography.
    Sho, K
    Takahashi, K
    Nambu, H
    Matsumura, M
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2001, 42 (04) : S79 - S79
  • [6] Quantitative Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography
    Wang, Tai-Ang
    Trung, Nguyen Hoang
    Lee, Hsiang-Chieh
    Lee, Cheng-Kuang
    Tsai, Meng-Tsan
    Wang, Yen-Li
    [J]. BIOENGINEERING-BASEL, 2023, 10 (11):
  • [7] Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats
    Wu, Shih-Fang
    Lin, Chih-Yao
    Tsai, Rong-Kung
    Wen, Yao-Tseng
    Lin, Feng-Huei
    Chang, Chia-Yu
    Shen, Ching-, I
    Lin, Shinn-Zong
    Harn, Horng-Jyh
    Chiou, Tzyy-Wen
    Liu, Chin-San
    Chen, Yan-Ting
    Su, Hong-Lin
    [J]. BIOMEDICINES, 2022, 10 (11)
  • [8] Changes in glutamate homeostasis cause retinal degeneration in Royal College of Surgeons rats
    Liu, Kang
    Wang, Yi
    Yin, Zhengqin
    Weng, Chuanhuang
    Zeng, Yuxiao
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 31 (05) : 1075 - 1080
  • [9] Changes in choroidal innervation in Royal College of Surgeons rats with hereditary retinal degeneration
    Rexer, M
    May, CA
    Lütjen-Drecoll, E
    [J]. ACTA ANATOMICA, 1998, 162 (2-3): : 112 - 118
  • [10] Ultrahigh resolution optical coherence tomography for quantitative topographic mapping of retinal and intraretinal architectural morphology
    Ko, T
    Hartl, I
    Drexler, W
    Ghanta, R
    Fujimoto, J
    [J]. COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS VI, 2002, 4619 : 223 - 226
12345