Reference viruses for seasonal and pandemic influenza vaccine preparation

被引：28

作者：

Wood, John M. ^{[1
]}

Robertson, James S. ^{[1
]}

机构：

[1] Natl Inst Biol Stand & Controls, Div Virol, Potters Bar EN6 3QG, Herts, England

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2007年 / 1卷 / 01期

关键词：

H5N1; high-growth reassortants; influenza vaccine viruses; pandemic vaccine strains; reverse genetics; seasonal vaccine strains;

D O I：

10.1111/j.1750-2659.2006.00003.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The production of seasonal and pandemic influenza vaccines depends on the timely availability of suitable reference viruses. Seasonal vaccines are traditionally produced from high-growth reassortant viruses, which have been derived empirically using well-established techniques. However, it is not possible to use such approaches in deriving vaccine reference viruses from highly pathogenic H5N1 viruses and alternative techniques such as reverse genetics must be employed.

引用

页码：5 / 9

页数：5

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