Autologous hematopoietic stem cell transplantation in type 1-diabetes

被引：6

作者：

Rosengren, Anders H. ^{[1
]}

Renstrom, Erik ^{[1
]}

机构：

[1] Lund Univ, Ctr Diabet, Malmo, Sweden

来源：

ISLETS | 2009年 / 1卷 / 01期

关键词：

pancreatic islets; transplantation; type; 1-diabetes; hematopietic stem cells; sitagliptin; BONE-MARROW-TRANSPLANTATION; DIABETES-MELLITUS; REGENERATION;

D O I：

10.4161/isl.1.1.8817

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A Type 1-diabetes results from autoimmune destruction of the insulin-producing beta-cells in the pancreas. Today there is no cure to the disorder, and the patients require life-long insulin medication to survive. Treatment with exogenous insulin cannot mimic the second-by-second regulation of blood glucose levels achieved by the beta-cells, and the current regimen presents a difficult navigation between the Scylla of life-threatening hypoglycemia and the Charybdis of hyperglycemic tissue glycosylation and late-complications.

引用

页码：81 / 83

页数：3

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