Biologically active glycosides from Asteroidea, 43.: Isolation and structure of a new neuritogenic-active ganglioside molecular species from the starfish Linckia laevigata

被引：26

作者：

Inagaki, M

Miyamoto, T

Isobe, R

Higuchi, R

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, Fukuoka 8128582, Japan

[2] Towa Univ, Dept Med Elect Engn, Fac Engn, Minami Ku, Fukuoka 8150036, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 12期

关键词：

glycosphingolipid; ganglioside; starfish; Linckia laevigata;

D O I：

10.1248/cpb.53.1551

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A ganglioside molecular species, LLC-5 (1), has been obtained from the water soluble lipid fraction of the CHCl3/MeOH extract of the starfish Linckia laevigata. On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. Negative ion FAB-MS provided important information both on the structure of the sugar moiety and on the molecular mass of the ganglioside. I is a new ganglioside molecular species possessing a 2 -> 11 linked linear-type trisialosyl moiety. Moreover, 1 exhibited neuritogenic activity in rat pheochro-mocytoma PC-12 cells in the presence of nerve growth factor.

引用

页码：1551 / 1554

页数：4

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