Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid

被引：100

作者：

Chen, Li ^{[2
,3
]}

Zhang, Yihua ^{[2
]}

Kong, Xiangwen ^{[2
]}

Lan, Edward ^{[1
]}

Huang, Zhangjian ^{[2
]}

Peng, Sixun ^{[2
]}

Kaufman, Daniel L. ^{[1
]}

Tian, Jide ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[2] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China

[3] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 15期

关键词：

D O I：

10.1021/jm800167u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel furoxan-based nitric oxide (NO) releasing derivatives of oleanolic acid (OA) were synthesized for potential therapy of liver cancers. Six compounds produced high levels of NO in human hepatocellular carcinoma (HCC) cells and exhibited strong cytotoxicity selectively against HCC in vitro. Treatment with 8b or 16b significantly inhibited the growth of HCC tumors in vivo. These data provide a proof-in-principle that furoxan/OA hybrids may be used for therapeutic intervention of human liver cancers.

引用

页码：4834 / 4838

页数：5

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