Commercial Serological Tests for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis: An Updated Systematic Review and Meta-Analysis

被引:175
|
作者
Steingart, Karen R. [1 ]
Flores, Laura L. [2 ,3 ]
Dendukuri, Nandini [4 ,5 ]
Schiller, Ian [4 ,5 ]
Laal, Suman [6 ,7 ,8 ]
Ramsay, Andrew [9 ]
Hopewell, Philip C. [2 ,3 ]
Pai, Madhukar [4 ,5 ]
机构
[1] Univ Washington, Sch Publ Hlth, Dept Hlth Serv, Washington, DC USA
[2] Univ Calif San Francisco, San Francisco Gen Hosp, Div Pulm & Crit Care Med, San Francisco, CA USA
[3] Univ Calif San Francisco, Curry Int TB Ctr, San Francisco, CA 94143 USA
[4] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada
[5] Chest Inst, Montreal, PQ, Canada
[6] NYU, Langone Med Ctr, Dept Pathol, New York, NY USA
[7] NYU, Langone Med Ctr, Dept Microbiol, New York, NY USA
[8] Vet Affairs Med Ctr, New York, NY USA
[9] WHO, WHO Special Programme Res & Training Trop Dis, World Bank, UNICEF,UNDP, CH-1211 Geneva, Switzerland
关键词
MYCOBACTERIAL ANTIGEN A60; HUMORAL IMMUNE-RESPONSE; RAPID SERODIAGNOSIS; CLINICAL-EVALUATION; ANTIBODY DETECTION; MYCODOT(TM) TEST; IGA; SENSITIVITY; ASSAY; GLYCOLIPIDS;
D O I
10.1371/journal.pmed.1001062
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Serological (antibody detection) tests for tuberculosis (TB) are widely used in developing countries. As part of a World Health Organization policy process, we performed an updated systematic review to assess the diagnostic accuracy of commercial serological tests for pulmonary and extrapulmonary TB with a focus on the relevance of these tests in low and middle-income countries. Methods and Findings: We used methods recommended by the Cochrane Collaboration and GRADE approach for rating quality of evidence. In a previous review, we searched multiple databases for papers published from 1 January 1990 to 30 May 2006, and in this update, we add additional papers published from that period until 29 June 2010. We prespecified subgroups to address heterogeneity and summarized test performance using bivariate random effects meta-analysis. For pulmonary TB, we included 67 studies (48% from low- and middle-income countries) with 5,147 participants. For all tests, estimates were variable for sensitivity (0% to 100%) and specificity (31% to 100%). For anda-TB IgG, the only test with enough studies for meta-analysis, pooled sensitivity was 76% (95% CI 63%-87%) in smear-positive (seven studies) and 59% (95% CI 10%-96%) in smear-negative (four studies) patients; pooled specificities were 92% (95% CI 74%-98%) and 91% (95% CI 79%-96%), respectively. Compared with ELISA (pooled sensitivity 60% [95% CI 6%-65%]; pooled specificity 98% [95% CI 96%-99%]), immunochromatographic tests yielded lower pooled sensitivity (53%, 95% CI 42%-64%) and comparable pooled specificity (98%, 95% CI 96%-99%). For extrapulmonary TB, we included 25 studies (40% from low-and middle-income countries) with 1,809 participants. For all tests, estimates were variable for sensitivity (0% to 100%) and specificity (59% to 100%). Overall, quality of evidence was graded very low for studies of pulmonary and extrapulmonary TB. Conclusions: Despite expansion of the literature since 2006, commercial serological tests continue to produce inconsistent and imprecise estimates of sensitivity and specificity. Quality of evidence remains very low. These data informed a recently published World Health Organization policy statement against serological tests.
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页数:18
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