Incorporation of novel ASO chemistries significantly improves the potency and durability of HBVASOs in the AAV-HBV mouse model

被引：0

作者：

Hong, Jin ^{[1
]}

Eltepu, Laxman ^{[1
]}

Montero, Saul Martinez ^{[1
]}

Tan, Hua ^{[1
]}

Hyunsoon, Kang ^{[1
]}

Rajwanshi, Vivek ^{[1
]}

Cortez, John ^{[1
]}

Cai, Dawei ^{[1
]}

Liu, Cheng ^{[1
]}

Rosler, Elen ^{[1
]}

Smith, David ^{[1
]}

Symons, Julian ^{[1
]}

Blatt, Lawrence ^{[1
]}

Beigelman, Leonid ^{[1
]}

机构：

[1] Aligos Therapeut, San Francisco, CA USA

来源：

JOURNAL OF HEPATOLOGY | 2022年 / 77卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

SAT402

引用

页码：S853 / S854

页数：2

共 19 条

[1] INCORPORATION OF NOVEL siRNA CHEMISTRIES SIGNIFICANTLY IMPROVES THE POTENCY AND DURABILITY OF HBV SIRNAS IN THE AAV-HBV MOUSE MODEL
Hong, Jin
Montero, Saul Martinez
Tan, Hua
Rajwanshi, Vivek K.
Kang, Hyunsoon
Sousa, Jacquelyn
Huang, Vera
Cai, Dawei
Rosler, Elen
Pandey, Rajendra
Blatt, Lawrence M.
Symons, Julian A.
Smith, David B.
Beigelman, Leonid N.
HEPATOLOGY, 2021, 74 : 509A - 510A
[2] STING AGONIST MEDIATES ANTIVIRAL EFFECTS IN AAV-HBV MOUSE MODEL
Zhang, Mingyuan
Niu, Junqi
HEPATOLOGY, 2021, 74 : 520A - 521A
[3] Retreatment with HBV siRNA Results in Additional Reduction in HBV Antigenemia and Immune Stimulation in the AAV-HBV Mouse Model
Van Gulck, Ellen
Conceicao-Neto, Nadia
Aerts, Liese
Pierson, Wim
Verschueren, Lore
Vleeschouwer, Mara
Krishna, Vinod
Najera, Isabel
Pauwels, Frederik
VIRUSES-BASEL, 2024, 16 (03):
[4] AAV-HBV mouse model replicates immune exhaustion patterns of chronic HBV patients at single-cell level
Zhu, Ren
Han, Qinglin
Neto, Nadia
Yao, Zhiyuan
Wu, Qun
de Maeyer, Dries
Van der Borght, Koen
Beyens, Matthias
Van Gulck, Ellen
Kukolj, George
Ondrej, Podlaha
Li, Chris
Najera, Isabel
JOURNAL OF HEPATOLOGY, 2023, 78 : S443 - S443
[5] mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model
De Pooter, Dorien
Pierson, Wim
Pourshahian, Soheil
Dockx, Koen
De Clerck, Ben
Najera, Isabel
Davis, Heather
Van Gulck, Ellen
Boden, Daniel
VACCINES, 2024, 12 (03)
[6] ELUCIDATING THE MECHANISMS OF HDV-INDUCED LIVER DAMAGE IN AN AAV-HBV/HDV COINFECTION MOUSE MODEL
Ramon, Gracian Camps
Maestro, Sheila
Usai, Carla
Olague, Cristina
Suarez, Lester
Vales, Africa
Hommel, Mirja
Aldabe, Rafael
Gonzalez-Aseguinolaza, Gloria
HEPATOLOGY, 2019, 70 : 632A - 632A
[7] The HBV siRNA, ALG-125755, demonstrates a favourable nonclinical profile and significant and durable hepatitis B surface antigen reductions in the AAV-HBV mouse efficacy model
Fitzgerald, Megan
Gupta, Kusum
Le, Kha
Mukherjee, Sucheta
Hong, Jin
Nguyen, Khiem
Chen, Alfred
Rajwanshi, Vivek
Williams, Caroline
Venkatraman, Meenakshi
McClure, Matthew
Chanda, Sushmita
Fry, John
Smith, David
Symons, Julian
Blatt, Lawrence
Beigelman, Leonid
Lin, Tse-I
JOURNAL OF HEPATOLOGY, 2022, 77 : S846 - S846
[8] Combination treatment of a PAPD5/7 inhibitor with an antisense oligonucleotide bepirovirsen with concurrent dosing shows additive HBsAg decreases in the AAV-HBV mouse model
Delahaye, Jared
Long, Edward
Lau, Chi
Parsons, Jacob
Wen, Bo
Cui, Zhiyi
Paff, Melanie
You, Shihyun
Leivers, Martin
JOURNAL OF HEPATOLOGY, 2022, 77 : S880 - S880
[9] LIVER-TARGETED INHIBITION OF PAPD5 AND PAPD7 LEADS TO SUSTAINABLE HBsAg REDUCTION IN THE AAV-HBV MOUSE MODEL.
Zhou, Xue
Yu, Youjun
Lopez, Anais
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Gylling, Helene
Friis, Gitte
Ottosen, Soren
Mueller, Henrik
HEPATOLOGY, 2019, 70 : 439A - 440A
[10] Combination treatment of a TLR7/8 dual agonist with an antisense oligonucleotide bepirovirsen and entecavir leads to additive HBsAg decline in the AAV-HBV mouse model
Qiu, Ke
Deng, Zhiling
He, Taiyu
Chen, Zhi-Wei
Yuan, Taichang
Tang, Guozhi
Peng, Ming-Li
Ren, Hong
JOURNAL OF HEPATOLOGY, 2024, 80 : S727 - S727

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