Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells

被引：32
|
作者：
Grandjenette, Cindy [1 ,2 ]
Kennel, Anne [1 ,2 ]
Faure, Gilbert C. [1 ,2 ]
Bene, Marie C. [1 ,2 ]
Feugier, Pierre [3 ]
机构：
[1] Nancy Univ, Fac Med, Lab Immunol, EA3441,IFR 111, F-54500 Vandoeuvre Les Nancy, France
[2] CHU Nancy, F-54500 Vandoeuvre Les Nancy, France
[3] CHU Nancy, Serv Hematol Adulte, F-54500 Vandoeuvre Les Nancy, France
来源：
HAEMATOLOGICA | 2007年 / 92卷 / 09期
关键词：
TLR; B-CLL; imiquimod; ODN;
D O I：
10.3324/haematol.10975
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study reports that B-chronic lymphocytic leukemia (B-CLL) cells display the same pattern of toll-like receptors (TLRs) proteins expression as normal B-cells, yet with overexpression of TLR9. Furthermore, TLR7 and TLR9 appear to be functional and liable to respond to specific ligands, respectively imidazoquinolines and CpG-ODN thus potentially opening new therapeutic approaches.
引用
收藏
页码：1279 / 1281
页数：3
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