Stereological Investigation of Age-Related Changes of the Capillaries in White Matter

被引：26
|
作者：
Shao, Wei-Hua [2 ]
Li, Chen [2 ,3 ]
Chen, Lin [2 ]
Qiu, Xuan [2 ]
Zhang, We
Huang, Chun-Xia [4 ]
Xia, Lei [2 ]
Kong, Ji-Ming [1 ,2 ]
Tang, Yong [1 ,2 ]
机构：
[1] Chongqing Med Univ, Coll Basic Med Sci, Dept Histol & Embryol, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Lab Stem Cells & Tissue Engn, Chongqing 400016, Peoples R China
[3] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
[4] Chongqing Med Univ, Dept Physiol, Chongqing 400016, Peoples R China
来源：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2010年 / 293卷 / 08期
关键词：
white matter; capillaries; rat; aging; stereology; LATERAL GENICULATE-NUCLEUS; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; CEREBRAL HYPOPERFUSION; RAT-BRAIN; LENGTH; LEUKOARAIOSIS; NUMBER; CORTEX; FLOW;
D O I：
10.1002/ar.21184
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
We, for the first time, investigated the age-related changes of the capillaries in white matter using immunohistochemistry and stereological techniques. Ten young female (7 months) and 10 aged female (27 months) rats were used. The total length, total volume, and total surface area of the capillaries in white matter of aged rats were all significantly lower than those of young rats. The age-related changes of the capillaries in white matter may have important implications for age-related white matter atrophy and age-related cognitive impairments. Anat Rec, 293:1400-1407, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：1400 / 1407
页数：8
相关论文
共 50 条
  • [1] Stereological quantification of age-related changes in myelinated fibers of rat white matter
    Li, Chen
    Zhang, Lei
    Chao, Fenglei
    Xiao, Qian
    Luo, Yanmin
    Tang, Yong
    [J]. NEUROREPORT, 2017, 28 (01) : 42 - 49
  • [2] Age-related white matter changes in Asia
    Xiong, Yun Yun
    Mok, Vincent
    [J]. NEUROLOGY ASIA, 2011, 16 (03) : 179 - 186
  • [3] Heterogeneity in age-related white matter changes
    Reinhold Schmidt
    Helena Schmidt
    Johannes Haybaeck
    Marisa Loitfelder
    Serge Weis
    Margherita Cavalieri
    Stephan Seiler
    Christian Enzinger
    Stefan Ropele
    Timo Erkinjuntti
    Leonardo Pantoni
    Philip Scheltens
    Franz Fazekas
    Kurt Jellinger
    [J]. Acta Neuropathologica, 2011, 122 : 171 - 185
  • [4] Heterogeneity in age-related white matter changes
    Schmidt, Reinhold
    Schmidt, Helena
    Haybaeck, Johannes
    Loitfelder, Marisa
    Weis, Serge
    Cavalieri, Margherita
    Seiler, Stephan
    Enzinger, Christian
    Ropele, Stefan
    Erkinjuntti, Timo
    Pantoni, Leonardo
    Scheltens, Philip
    Fazekas, Franz
    Jellinger, Kurt
    [J]. ACTA NEUROPATHOLOGICA, 2011, 122 (02) : 171 - 185
  • [5] Stereological Investigation of Age-Related Changes of Myelinated Fibers in the Rat Cortex
    Zhang, Wei
    Yang, Shu
    Li, Chen
    Chen, Lin
    Tang, Yong
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2009, 87 (13) : 2872 - 2880
  • [6] Age-related white matter changes and cognitive impairment
    Inzitari, D
    [J]. ANNALS OF NEUROLOGY, 2000, 47 (02) : 141 - 143
  • [7] Age-related white matter changes and cognitive impairment
    Ferro, JM
    Madureira, S
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2002, 203 : 221 - 225
  • [8] The prognostic significance of age-related white matter changes
    Inzitari, D
    [J]. INTERNATIONAL PSYCHOGERIATRICS, 2005, 17 : 51 - 52
  • [9] Pathophysiology of age-related cerebral white matter changes
    Pantoni, L
    [J]. CEREBROVASCULAR DISEASES, 2002, 13 : 7 - 10
  • [10] Age-induced white matter changes in the human brain: A stereological investigation
    Tang, Y
    Nyengaard, JR
    Pakkenberg, B
    Gundersen, HJG
    [J]. NEUROBIOLOGY OF AGING, 1997, 18 (06) : 609 - 615
12345