Apoptosis in maternal peripheral blood during pregnancy

被引：25

作者：

Kolialexi, A ^{[1
]}

Tsangaris, GT ^{[1
]}

Antsaklis, A ^{[1
]}

Tzortzatou, F ^{[1
]}

Amentas, C ^{[1
]}

Koratzis, A ^{[1
]}

Mavrou, A ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Genet Unit, Dept Pediat 1, GR-11527 Athens, Greece

来源：

FETAL DIAGNOSIS AND THERAPY | 2001年 / 16卷 / 01期

关键词：

apoptosis rate; maternal peripheral blood; pregnancy; chromosomally normal fetuses; chromosomally abnormal fetuses;

D O I：

10.1159/000053877

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To investigate the mononuclear cell apoptosis rate during pregnancy. Materials and Methods: Apoptosis was quantitated by EtBr staining in whole peripheral blood samples of 135 women in different gestational weeks and 85 nonpregnant women used as controls. Apoptosis was also qualitated by TUNEL assay, Results: The apoptosis rate increased during pregnancy according to gestational age, In chromosomally abnormal fetuses apoptosis was 2.5-fold higher than that found in pregnancies with normal embryos matched for gestational age. FISH in TUNEL-positive cells using X, Y and 21 chromosome probes verified the fetal origin of part of the apoptotic population. Conclusion: Apoptosis is stimulated in maternal peripheral blood during pregnancy, possibly accounting partly for the presence of free fetal DNA in maternal serum. The increased apoptosis rate in pregnancies with chromosomally abnormal fetuses may have additional clinical importance. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：32 / 37

页数：6

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