Effects of lipopolysaccharide on production of interleukin-1 and interleukin-6 by bovine mammary epithelial cells in vitro

被引：31
|
作者：
Okada, H [1 ]
Ohtsuka, H
Kon-Nai, S
Kirisawa, R
Yokomizo, Y
Yoshino, T
Rosol, TJ
机构：
[1] Rakuno Gakuen Univ, Dept Vet Pathol, Ebetsu, Hokkaido 0698501, Japan
[2] Rakuno Gakuen Univ, Vet Teaching Hosp, Ebetsu, Hokkaido 0698501, Japan
[3] Rakuno Gakuen Univ, Dept Vet Microbiol, Ebetsu, Hokkaido 0698501, Japan
[4] Natl Inst Anim Hlth, Tsukuba, Ibaraki 3050856, Japan
[5] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 1999年 / 61卷 / 01期
关键词：
cytokine; lipopolysaccharide; mammary;
D O I：
10.1292/jvms.61.33
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This investigation was performed to determine the effect of lipopolysaccharide (LPS) on production of interleukin (IL)-1 and IL-6 by bovine mammary epithelial cells in vitro. After confluence, the cells were stimulated with LPS (0.1, 1.0 or 10 mu g/ml) for 4, 8, 24, and 48 hr. LPS increased production of both IL-1 and IL-6 production from mammary cells in a dose dependent manner. The expression of mRNA for IL-1 receptor antagonist (IL-1ra) was demonstrated by reverse transcription-polymerase chain reaction in bovine mammary epithelial cells.
引用
收藏
页码：33 / 35
页数：3
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