Background/objectives. - According to the reported cases, more than 100 athletes were infected with severe acute respiratory syndrome coronavirus 2 in March 2020 alone, and this has created an increased interest in the effect of coronavirus disease (COVID-19) on athletes. This promoted us to study the spread of COVID-19 in athletes and formulate prevention strategies. Methodology. - We collected and analyzed the demographic information, such as nationality, sex, age, name, sport played, sport level, source and cause of infection, date of symptoms onset or confirmation of positive status, date of recovery, location of infection contraction, symptoms, and the people infected by the contracted athletes, of 521 infected athletes worldwide, as of the end of July, 2020. Results. - The cohort comprised 95.49% male athletes; 57.2% were aged 19-35 years, with the average age 23 years. Most of these cases emerged in March 2020 (27.3%) and June 2020 (30.1%), 90.8% of cases were active athletes and 74.2% were professional players, 45.2% of infected athletes exhibited mild symptoms and 30.6% of them were asymptomatic; however, 23.1% of the cases died, including cases aged less than 40 years. Most infected athletes represented soccer (46.6%), football (15.9%), and basketball (10.9%). Most of the infected athletes were from the United States, Western Europe, and Eastern Asia. The athletes primarily contracted the infection in the United States, Western Europe, and Japan. The spread of COVID-19 in these athletes primarily occurred during training- and game-related activities. More than 60% of the infected athletes were unaware of their source of infection. Conclusion. - It found that the halting of training and matches, isolation of athletes at home, and timely testing can effectively control the spread of COVID-19 among athletes, and it is recommended that athletes discontinue international travel, especially to countries with a high epidemic risk. (C) 2021 Elsevier Masson SAS. All rights reserved.