[1] Inst Bergonie, INSERM, U1218, 229 Cours Argonne, F-33076 Bordeaux, France
[2] Univ Bordeaux, INSERM, U1218, ACT Lab,IECB, F-33600 Pessac, France
[3] Inst Bergonie, Early Phase Trials Unit, 229 Cours Argonne, F-33076 Bordeaux, France
[4] Univ Bordeaux, Bordeaux, France