Self-assembled liposomes from amphiphilic electrospun nanofibers

被引：57
|
作者：
Yu, Deng-Guang [1 ]
Branford-White, Christopher [2 ]
Williams, Gareth R. [2 ]
Bligh, S. W. Annie [2 ]
White, Kenneth [2 ]
Zhu, Li-Min [3 ]
Chatterton, Nicholas P. [2 ]
机构：
[1] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, Shanghai 200093, Peoples R China
[2] London Metropolitan Univ, Inst Hlth Res & Policy, Fac Life Sci, London N7 8DB, England
[3] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
来源：
SOFT MATTER | 2011年 / 7卷 / 18期
基金：
中国博士后科学基金;
关键词：
PHOSPHOLIPID COMPLEX; PHARMACOKINETICS; SURFACTANTS; SYSTEM; RATS; LIFE; NMR;
D O I：
10.1039/c1sm05961k
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1-33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.
引用
收藏
页码：8239 / 8247
页数：9
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