Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw

被引：0
|
作者：
Bacian Martinez, Sandra [1 ]
Navarro Cuellar, Carlos [1 ]
Navarro Vila, Carlos [1 ]
Palacios Weiss, Edurne [1 ]
Pujol Romanya, Roser [1 ]
Fernandez de Velasco, Alvaro del Amo [1 ]
Escrig de Teijeiro, Margarita [1 ]
del Castillo Pardo de Vera, Jose Luis [1 ]
Rodriguez Perez, Irene [2 ]
Sanchez-Perez, Arturo [3 ]
Zamorano-Leon, Jose J. [4 ]
Lopez-Farre, Antonio [4 ]
Garcia-Hidalgo Alonso, Maria Isabel [5 ]
Navarro Cuellar, Ignacio [1 ]
机构：
[1] Hosp Univ HLA Mondoa, Maxillofacial Surg Dept, Madrid 28008, Spain
[2] Hosp Univ HLA Moncloa, Pathol Dept, Madrid 28008, Spain
[3] Murcia Univ, Fac Med, Murcia 30008, Spain
[4] Univ Complutense Madrid, Fac Med, Madrid 28040, Spain
[5] Hosp Puerta de Hierro, Radiol Dept, Madrid 28222, Spain
来源：
APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 16期
关键词：
denosumab; medication related osteonecrosis of the jaw (MRNOJ); primary intraosseous squamous cell carcinoma; MEDICATION-RELATED OSTEONECROSIS; ZOLEDRONIC ACID; CANCER;
D O I：
10.3390/app11167646
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.
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页数：7
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