Photostable fluorescent probes based on multifunctional group substituted naphthalimide dyes for imaging of lipid droplets in live cells

被引：2

作者：

Li, Xinwei ^{[1
]}

Bian, Jiqing ^{[1
]}

Fu, Mingyang ^{[1
]}

Zhang, Yan ^{[1
]}

Liu, Hongmei ^{[1
,3
]}

Gao, Baoxiang ^{[1
,2
,3
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

[2] Hebei Univ, Key Lab Analyt Sci & Technol Hebei Prov, Baoding 071002, Hebei, Peoples R China

[3] Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Hebei, Peoples R China

来源：

ANALYTICAL METHODS | 2022年 / 14卷 / 12期

基金：

中国国家自然科学基金;

关键词：

DIIMIDES SYNTHESIS; ELECTRON-TRANSFER; FLUOROPHORES; SHIFT;

D O I：

10.1039/d2ay00104g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We designed and synthesized multifunctional group substituted naphthalimide (MFGNI) dyes by introducing glycine ethyl ester and azetidine on 1,8-naphthalimide. With different azetidine substituents, the emission of the MFGNI dyes was shifted from blue to green. These MFGNI dyes exhibited high photoluminescence quantum yields (61% to 85%) and large Stokes shifts (67 nm). The amides and hydroxyl groups improved the photostability of the MFGNI dyes. Due to the small molecular weight and lipophilic properties, these MFGNI dyes specifically stained lipid droplets in living cells.

引用

页码：1279 / 1284

页数：6

共 50 条

[1] Fluorescent probes based on multifunctional encapsulated perylene diimide dyes for imaging of lipid droplets in live cells
Li, Xinwei
Yang, Zikang
Bian, Jiqing
Fu, Mingyang
Zhang, Yan
Jiang, Nan
Qiao, Yanjun
Chen, Hua
Gao, Baoxiang
[J]. ANALYST, 2022, 147 (07) : 1410 - 1416
[2] Fluorescent probes for the imaging of lipid droplets in live cells
Tian, He, Jr.
Sedgwick, Adam C.
Han, Hai-Hao
Sen, Sajal
Chen, Guo-Rong
Zang, Yi
Sessler, Jonathan L.
James, Tony D.
Li, Jia
He, Xiao-Peng
[J]. COORDINATION CHEMISTRY REVIEWS, 2021, 427
[3] Photostable fluorescent probes for 3D imaging and monitoring the metabolism of lipid droplets
Wang, Kang-Nan
Peng, Xiang-Jun
Li, Yi
Tang, Hai-Tao
Pan, Ying-Ming
He, Liang
[J]. DYES AND PIGMENTS, 2020, 180
[4] Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes
Dadina, N.
Tyson, J.
Zheng, S.
Lesiak, L.
Schepartz, A.
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2021, 65 : 154 - 162
[5] Aminoindole and naphthalimide based charge transfer fluorescent probes for pH sensing and live cell imaging
Sharma, Sushil
Srinivas, Sai
Rakshit, Sabyasachi
Sengupta, Sanchita
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2022, 20 (47) : 9422 - 9430
[6] Squaraine probes for the bimodal staining of lipid droplets and endoplasmic reticulum imaging in live cells
Ferdinandus
Tan, Jie Ren
Lim, Jin Heng
Arai, Satoshi
Sou, Keitaro
Lee, Chi-Lik Ken
[J]. ANALYST, 2022, 147 (15) : 3570 - 3577
[7] New photostable naphthalimide-based fluorescent probe for mitochondrial imaging and tracking
Huang, Saipeng
Han, Rongcheng
Zhuang, Qianfen
Du, Libo
Jia, Hongying
Liu, Yangping
Liu, Yang
[J]. BIOSENSORS & BIOELECTRONICS, 2015, 71 : 313 - 321
[8] Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells
Oberg, Elisabet
Appelqvist, Hanna
Nilsson, K. Peter R.
[J]. FRONTIERS IN CHEMISTRY, 2017, 5
[9] A deep-red emission AIE fluorescent probes based on coumarin for imaging lipid droplets in living cells
Yang, Jing
Wang, Zhiyu
Ge, Jiayi
Deng, Yi
Ding, Feiyang
Hu, Lei
Wang, Hui
[J]. JOURNAL OF MOLECULAR STRUCTURE, 2023, 1277
[10] Rational design fluorescent dyes based on morpholine derivatives for specific imaging of lysosomes and lipid droplets in living cells
Yang, Jing
Chen, Dandan
Wang, Zhiyu
Wang, Yuqing
Li, Jiale
Wang, Jie
Zhang, Cuifeng
Shen, Xuebin
Hu, Lei
Wang, Hui
[J]. DYES AND PIGMENTS, 2024, 221

← 1 2 3 4 5 →