Tumour-Targeted Drug Delivery with Mannose-Functionalized Nanoparticles Self-Assembled from Amphiphilic β-Cyclodextrins

被引：87

作者：

Ye, Zhou ^{[1
,2
]}

Zhang, Quan ^{[1
,2
]}

Wang, Shengtao ^{[1
]}

Bharate, Priya ^{[2
]}

Varela-Aramburu, Silvia ^{[2
]}

Lu, Mengji ^{[3
]}

Seeberger, Peter H. ^{[2
]}

Yin, Jian ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China

[2] Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, Muhlenberg 1, D-14476 Potsdam, Germany

[3] Univ Hosp Essen, Inst Virol, Virchowstr 179, D-45147 Essen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 43期

基金：

中国国家自然科学基金;

关键词：

cancer chemotherapy; mannose-mediated targeting; multivalency; nanoparticles; targeted drug delivery; MESOPOROUS SILICA NANOPARTICLES; GOLD NANOPARTICLES; RELEASE; NANOCARRIERS; NANOSYSTEMS; DERIVATIVES; COMPLEXES; MICELLES; PLATFORM;

D O I：

10.1002/chem.201603294

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multivalent mannose-functionalized nanoparticles self-assembled from amphiphilic beta-cyclodextrins (beta-CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin ( DOX)-loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor-mediated endocytosis by MDA-MB-231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX-loaded nanoparticles to inhibit the growth of MDA-MB-231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment.

引用

页码：15216 / 15221

页数：6

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