Diagnostic Classification of Retinal Nerve Fiber Layer Measurement in Myopic Eyes: A Comparison Between Time-Domain and Spectral-Domain Optical Coherence Tomography

PURPOSE: To evaluate and compare the diagnostic classification of retinal nerve fiber layer (RNFL) measurement between time-domain and spectral-domain optical coherence tomography (OCT) in myopic eyes. DESIGN: Prospective, observational study. METHODS: A total of 97 eyes from 97 healthy myopic subjects were included. The RNFL in each eye was imaged sequentially with the Stratus OCT and the Cirrus HD-OCT (Carl Zeiss Meditec). With reference to the built-in normative database, the number of abnormal diagnostic classifications (borderline or outside normal limits) in each OCT device was analyzed and compared using the likelihood ratio chi-square test. Multiple logistic regression analysis was performed to evaluate factors associated with abnormal diagnostic classification. RESULTS: The Cirrus HD-OCT classified a significantly higher percentage of eyes as outside normal limits/borderline in at least 1 clock hour (Stratus, 14.4%/24.8%; Cirrus, 21.6%/34.1%; all P < .01). RNFL measurement at 1 (23.6%) and 2 o'clock (23.5%) of all eyes was the most frequent location classified as abnormal by the Cirrus HD-OCT and the Stratus OCT, respectively. Eyes with smaller optic disc and longer axial length were more likely to have abnormal diagnostic classification. CONCLUSIONS: In myopic eyes, Cirrus HD-OCT was more likely to have abnormal diagnostic classification than the Stratus OCT. (Am J Ophthalmol 2011;152: 646-653. (C) 2011 by Elsevier Inc. All rights reserved.)