Cow milk angiogenin induces cytokine production in human blood leukocytes

Angiogenin isolated from cow milk induces the production of cytokines IL-Ibeta, IL-6, and TNF-alpha in human leukocytes; the level of production of each cytokine depends on the concentration of the preparation, and the dynamics of production depends on the time from the beginning of induction. Simultaneous treatment with angiogenin and phytollemagglutinin had an additive effect on the production of cytokines, the time of this effect manifestation being individual for each cytokine.