Modelling collective cell migration of neural crest

被引:32
|
作者
Szabo, Andras [1 ]
Mayor, Roberto [1 ]
机构
[1] UCL, Dept Cell & Dev Biol, Gower St, London WC1E 6BT, England
基金
英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
CONTACT INHIBITION; MESENCHYMAL CELLS; MECHANISMS; TRUNK; COMMUNICATION; CHEMOTAXIS; TRANSITION; PLASTICITY; LOCOMOTION; GUIDANCE;
D O I
10.1016/j.ceb.2016.03.023
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Collective cell migration has emerged in the recent decade as an important phenomenon in cell and developmental biology and can be defined as the coordinated and cooperative movement of groups of cells. Most studies concentrate on tightly connected epithelial tissues, even though collective migration does not require a constant physical contact. Movement of mesenchymal cells is more independent, making their emergent collective behaviour less intuitive and therefore lending importance to computational modelling. Here we focus on such modelling efforts that aim to understand the collective migration of neural crest cells, a mesenchymal embryonic population that migrates large distances as a group during early vertebrate development. By comparing different models of neural crest migration, we emphasize the similarity and complementary nature of these approaches and suggest a future direction for the field. The principles derived from neural crest modelling could aid understanding the collective migration of other mesenchymal cell types.
引用
收藏
页码:22 / 28
页数:7
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