Synthesis of α,α-disubstituted-α-amino acids by double nucleophilic addition to cyanohydrins

被引：31

作者：

Charette, AB ^{[1
]}

Gagnon, A ^{[1
]}

Janes, M ^{[1
]}

Mellon, C ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 29期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)00983-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of tertiary carbinamines was achieved by the double nucleophilic addition of Grignard reagents to cyanohydrins. Titanium isopropoxide was found to promote the process. In a typical example, the rapid conversion of a carbinamine to the corresponding alpha,alpha-disubsrituted-alpha-amino acid was also demonstrated. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5147 / 5150

页数：4

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