Asymmetric synthesis of [7]helicene-like molecules

被引：73

作者：

Stará, IG ^{[1
]}

Alexandrová, Z ^{[1
]}

Teply, F ^{[1
]}

Sehnal, P ^{[1
]}

Stary, I ^{[1
]}

Saman, D ^{[1
]}

Budesínsky, M ^{[1
]}

Cvacka, J ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague, Czech Republic

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol047311p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to nonracemic [7]helicene-like molecules has been developed. Stereoselective Col-mediated [2 + 2 + 2] cycloisomerization of aromatic triynes containing an asymmetric carbon atom produces [7]helicene-like scaffolds in diastereomeric ratios up to 100:0. This central-to-helical chirality transfer can be controlled by the absolute configuration at the asymmetric center and by the presence of carbon substituents.

引用

页码：2547 / 2550

页数：4

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