Human dendritic cells in allergic asthma and rhinitis

被引：9
|
作者：
Froidure, Antoine [1 ]
Pilette, Charles [1 ,2 ]
机构：
[1] Catholic Univ Louvain, Inst Rech Expt & Clin, Walloon Inst Excellence Lifesci & Biotechnol WELB, B-1200 Brussels, Belgium
[2] Clin Univ St Luc, Serv Pneumol, B-1200 Brussels, Belgium
来源：
M S-MEDECINE SCIENCES | 2015年 / 31卷 / 02期
关键词：
HOUSE-DUST MITE; FC-EPSILON-RI; AIRWAY INFLAMMATION; TH2; RESPONSES; SERUM IGE; TSLP; RECEPTOR; TYPE-2; IDENTIFICATION; SENSITIZATION;
D O I：
10.1051/medsci/20153102011
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The role of dendritic cells (DC) in the pathogenesis of allergic asthma and rhinitis has been highlighted for 15 years. In this review, we summarize key findings concerning DC function in airway allergy and focus on studies performed in human. DC coming from allergic patients have specific characteristics, including significant expression of high affinity receptor for IgE as well as a propensity for Th2 responses induction following priming with allergen and/or epithelial cytokines. Mechanistic data concerning this DC dysfunction in asthma also provide perspectives for innovating therapies.
引用
收藏
页码：151 / 158
页数：8
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