A model of cardiac cellular electromechanics

被引：53
|
作者：
Nickerson, DP
Smith, NP
Hunter, PJ
机构：
[1] Univ Auckland, Auckland 1, New Zealand
[2] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2001年 / 359卷 / 1783期
关键词：
cardiac electromechanics; mathematical modelling; cellular mechanics;
D O I：
10.1098/rsta.2001.0823
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A coupled electromechanics model of a single cardiac cell is used to interpret a wide variety of experimental tests and is compared to a limited extent (since no other cardiac model dealing with the full range of mechanical tests is available) with other models of myofilament mechanics. We consider the passive elasticity of the cell, troponin-C-calcium binding kinetics, thin filament kinetics, the length dependence of steady-state tension, cross-bridge kinetics, and the coupling of mechanics to cell electrophysiology (the Noble 98 model) via the calcium transient.
引用
收藏
页码：1159 / 1172
页数：14
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