Discovery of small molecule inhibitors of the vitamin D receptor-coregulator interactions as transcriptional regulators for the 24-hydroxylase gene CYP24A1

被引:0
|
作者
Arnold, Alexander [1 ]
Nandhikonda, Premchendar [1 ]
Lynt, Wen Z. [1 ]
McCallum, Megan M. [1 ]
Baranowski, Athena [1 ]
Ara, Tahniyath [1 ]
机构
[1] Univ Wisconsin, Dept Chem & Biochem, Milwaukee, WI 53211 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 242卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
22-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Genetic Defect in CYP24A1, the Vitamin D 24-Hydroxylase Gene, in a Patient with Severe Infantile Hypercalcemia
    Dauber, Andrew
    Nguyen, Thutrang T.
    Sochett, Etienne
    Cole, David E. C.
    Horst, Ronald
    Abrams, Steven A.
    Carpenter, Thomas O.
    Hirschhorn, Joel N.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (02): : E268 - E274
  • [2] Epigenetic Regulation of Vitamin D 24-Hydroxylase/CYP24A1 in Human Prostate Cancer
    Luo, Wei
    Karpf, Adam R.
    Deeb, Kristin K.
    Muindi, Josephia R.
    Morrison, Carl D.
    Johnson, Candace S.
    Trump, Donald L.
    CANCER RESEARCH, 2010, 70 (14) : 5953 - 5962
  • [3] Analysis of the binding sites of vitamin D 1α-hydroxylase (CYP27B1) and vitamin D 24-hydroxylase (CYP24A1) for the design of selective CYP24A1 inhibitors: Homology modelling, molecular dynamics simulations and identification of key binding requirements
    Taban, Ismail M.
    Zhu, Jinge
    DeLuca, Hector F.
    Simons, Claire
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (20) : 5629 - 5636
  • [4] Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate
    Deeb, Kristin K.
    Luo, Wei
    Karpf, Adam R.
    Omilian, Angela R.
    Bshara, Wiam
    Tian, Lili
    Tangrea, Michael A.
    Morrison, Carl D.
    Johnson, Candace S.
    Trump, Donald L.
    EPIGENETICS, 2011, 6 (08) : 994 - 1000
  • [5] Alternative splicing of human vitamin D 24-hydroxylase (CYP24) gene.
    Ren, S
    Nuyen, L
    Hewison, M
    Adams, JS
    JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S107 - S107
  • [6] Small-Molecule Inhibitors of 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1): Synthesis and Biological Evaluation
    Ferla, Salvatore
    Aboraia, Ahmed S.
    Brancale, Andrea
    Pepper, Christopher J.
    Zhu, Jinge
    Ochalek, Justin T.
    DeLuca, Hector F.
    Simons, Claire
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (18) : 7702 - 7715
  • [7] Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-Hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis
    Dinour, Dganit
    Beckerman, Pazit
    Ganon, Liat
    Tordjman, Karen
    Eisenstein, Zemach
    Holtzman, Eli J.
    JOURNAL OF UROLOGY, 2013, 190 (02): : 552 - 557
  • [8] 24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders
    Azer, Sarah M.
    Vaughan, Lisa E.
    Tebben, Peter J.
    Sas, David J.
    JOURNAL OF THE ENDOCRINE SOCIETY, 2021, 5 (09)
  • [9] Small molecule inhibitors of CYP24A1 for treatment of various cancers
    Ferla, Salvatore
    Brancale, Andrea
    DeLuca, Hector F.
    Zhu, Grace J.
    Simons, Claire
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [10] Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis
    Sayer, John A.
    EUROPEAN UROLOGY, 2015, 68 (01) : 164 - 165