Mutations in 23S rRNA in Helicobacter pylori conferring resistance to erythromycin do not always confer resistance to clarithromycin

被引：33
|
作者：
García-Arata, MI
Baquero, F
de Rafael, L
de Argila, CM
Gisbert, JP
Bermejo, F
Boixeda, D
Cantón, R
机构：
[1] Hosp Ramon & Cajal, Dept Microbiol, E-28034 Madrid, Spain
[2] Hosp Ramon & Cajal, Dept Gastroenterol, E-28034 Madrid, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期
关键词：
D O I：
10.1128/AAC.43.2.374
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of >256 mu g/ml, whereas mutants carrying A2143G had MICs ranging from less than or equal to 0.016 to >256 mu g/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.
引用
收藏
页码：374 / 376
页数：3
相关论文
共 50 条
  • [1] Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori
    Versalovic, J
    Shortridge, D
    Kibler, K
    Griffy, MV
    Beyer, J
    Flamm, RK
    Tanaka, SK
    Graham, DY
    Go, MF
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) : 477 - 480
  • [2] Mutations in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance
    Kim, KS
    Kang, JO
    Eun, CS
    Han, DS
    Choi, TY
    [J]. JOURNAL OF KOREAN MEDICAL SCIENCE, 2002, 17 (05) : 599 - 603
  • [3] Clarithromycin resistance and 23S rRNA mutations in Helicobacter pylori isolates in Iran
    Kargar, Mohammad
    Baghernejad, Maryam
    Doosti, Abbas
    Ghorbani-Dalini, Sadegh
    [J]. AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2011, 5 (08): : 853 - 856
  • [4] Preferential A to G mutation in the 23S rRNA in Helicobacter pylori conferring resistance to clarithromycin.
    DebetsOssenkopp, YJ
    vanderBijl, MW
    Kusters, JG
    Kuipers, EJ
    VandenbrouckeGrauls, CMJE
    [J]. GASTROENTEROLOGY, 1997, 112 (04) : A955 - A955
  • [5] PREVALENCE OF THE POINT MUTATIONS IN 23S RRNA GENE CONFERRING TO THE CLARITHROMYCIN RESISTANCE OF HELICOBACTER PYLORI STRAINS - CORRELATION BETWEEN MUTATIONS AND DIFFERENT LEVELS OF RESISTANCE
    Klesiewicz, K.
    Karczewska, E.
    Nowak, P.
    Sito, E.
    Wojtas-Bonior, I.
    Budak, A.
    [J]. HELICOBACTER, 2014, 19 : 150 - 151
  • [6] Mutations in the 23S rRNA gene are associated with clarithromycin resistance in Helicobacter pylori isolates in Brazil
    Marcelo L Ribeiro
    Lea Vitiello
    Maira CB Miranda
    Yune HB Benvengo
    Anita PO Godoy
    Sergio Mendonca
    José Pedrazzoli
    [J]. Annals of Clinical Microbiology and Antimicrobials, 2 (1)
  • [7] Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children
    Cagan-Appak, Yeliz
    Gazi, Horu
    Ayhan, Semin
    Cengiz-Ozyurt, Beyhan
    Kurutepe, Semra
    Kasirga, Erhun
    [J]. TURKISH JOURNAL OF PEDIATRICS, 2016, 58 (04) : 371 - 376
  • [8] Mutations in the 23S rRNA genes of Helicobacter pylori mediate resistance to clarithromycin (A preliminary study)
    Ergin, S.
    Kocazeybek, B.
    Caliskan, R.
    Demiryas, S.
    Dinc, O.
    Gulergun, R.
    Tokman, H. Bahar
    Ziver, T.
    Saribas, S.
    Yuksel, P.
    Kalayci, F.
    Demirci, M.
    Tasci, I.
    Erzin, Y.
    Bal, K.
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 73 : 127 - 128
  • [9] Eradication of Helicobacter pylori According to 23S rRNA Point Mutations Associated With Clarithromycin Resistance
    Lee, Hyun Jeong
    Kim, Jin Il
    Cheung, Dae Young
    Kim, Tae Ho
    Jun, Eun-Jung
    Oh, Jung Hwan
    Chung, Woo Chul
    Kim, Byung-Wook
    Kim, Sung Soo
    [J]. GASTROENTEROLOGY, 2013, 144 (05) : S566 - S566
  • [10] Helicobacter pylori 23S rRNA gene mutations associated with clarithromycin resistance in chronic gastritis in Vietnam
    Van Huy Tran
    Thi Minh Thi Ha
    Phan Tuong Quynh Le
    Viet Nhan Nguyen
    Trung Nam Phan
    Paglietti, Bianca
    [J]. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2018, 12 (07): : 526 - 532
12345