Intramolecular ene reaction on a bicyclo[3.2.1]octane system: an alternative route to (-)-kainic acid

被引：29

作者：

Hirasawa, H ^{[1
]}

Taniguchi, T ^{[1
]}

Ogasawara, K ^{[1
]}

机构：

[1] Tohoku Univ, Inst Pharmaceut, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(01)01558-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intramolecular ene reaction of the 1,6-diene on a bicyclo[3.2.1]octane framework proceeds in a highly diastereoselective manner to form a trisubstituted pyrrolidine on the pyran ring in excellent yield. Its stereochemistry has been determined unambiguously by converting it into the known compound serving as a key intermediate of (-)-kainic acid. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7587 / 7590

页数：4

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