Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide

被引：16
|
作者：
Matsuoka, Shigeru
Shinohara, Naoki
Takahashi, Tomoaki
Iida, Maiko
Inoue, Masayuki [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 21期
关键词：
biological activity; ion channels; natural products; nonribosomal peptides; structure-activity relationships; MARINE SPONGE; GRAMICIDIN-A; PROTEIN-SYNTHESIS; ION-TRANSPORT; THIOESTER; ASSAY; POLYPEPTIDES; MEMBRANE; BILAYER;
D O I：
10.1002/anie.201101533
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Longer is better: PolytheonamideB, the largest nonribosomal linear peptide identified to date, is a transmembrane channel-forming peptide. Nine of its substructures have now been chemically synthesized. The membrane-disrupting and ion-channel-forming sequences as well as the cytotoxicity-enhancing sequence have been identified. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4879 / 4883
页数：5
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