BMI and low vitamin D are causal factors for multiple sclerosis A Mendelian Randomization study

被引:62
|
作者
Jacobs, Benjamin M. [1 ,2 ]
Noyce, Alastair J. [1 ,2 ]
Giovannoni, Gavin [1 ,2 ]
Dobson, Ruth [1 ,2 ]
机构
[1] Barts & Queen Mary Univ London, Prevent Neurol Unit, Wolfson Inst Prevent Med, London, England
[2] Barts Hlth NHS Trust, Royal London Hosp, London, England
来源
关键词
CHILDHOOD;
D O I
10.1212/NXI.0000000000000662
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective To update the causal estimates for the effects of adult body mass index (BMI), childhood BMI, and vitamin D status on multiple sclerosis (MS) risk. Methods We used 2-sample Mendelian randomization to determine causal estimates. Summary statistics for SNP associations with traits of interest were obtained from the relevant consortia. Primary analyses consisted of random-effects inverse-variance-weighted meta-analysis, followed by secondary sensitivity analyses. Results Genetically determined increased childhood BMI (ORMS 1.24, 95% CI 1.05-1.45, p = 0.011) and adult BMI (ORMS 1.14, 95% CI 1.01-1.30, p = 0.042) were associated with increased MS risk. The effect of genetically determined adult BMI on MS risk lessened after exclusion of 16 variants associated with childhood BMI (ORMS 1.11, 95% CI 0.97-1.28, p = 0.121). Correcting for effects of serum vitamin D in a multivariate analysis did not alter the direction or significance of these estimates. Each genetically determined unit increase in the natural-log-transformed vitamin D level was associated with a 43% decrease in the odds of MS (OR 0.57, 95% CI 0.41-0.81, p = 0.001). Conclusions We provide novel evidence that BMI before the age of 10 is an independent causal risk factor for MS and strengthen evidence for the causal role of vitamin D in the pathogenesis of MS.
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页数:6
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