Localizing functional activity in the brain through time-frequency analysis and synthesis of the EEG

Multichannel electroencephalograms (EEG's) are processed using time-frequency (TF) analysis and synthesis techniques to geometrically localize neuroelectric generators of specific activity contained within the observed EEG. The TF domain techniques are utilized to separate the signals of interest from the remainder of the EEG, by allowing the definition of regions of interest,which contain the signals for which we desire to localize the underlying neuronal generators. This approach essentially introduces a filtering technique which allows the distortionless separation of the signals of interest from all other components recorded. The source of the functional activity in the brain is estimated and mapped numerically by a least-squares approach. We have applied these techniques to identify the anatomical location of the sleep spindle, a component of the EEG observed during sleep, which is of importance in understanding the generation of sleep and sleep patterns.