The Role of Xist in X-Chromosome Dosage Compensation

被引：99
|
作者：
Sahakyan, Anna [1 ]
Yang, Yihao [1 ]
Plath, Kathrin [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Dept Biol Chem,Mol Biol Inst,Jonsson Comprehens C, Los Angeles, CA 90095 USA
来源：
TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 12期
关键词：
PLURIPOTENT STEM-CELLS; INACTIVATION CENTER; NONCODING RNA; CHROMATIN-STRUCTURE; DNA METHYLATION; GENE; NAIVE; MAINTENANCE; REACTIVATION; EXPRESSION;
D O I：
10.1016/j.tcb.2018.05.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In each somatic cell of a female mammal one X chromosome is transcriptionally silenced via X-chromosome inactivation (XCI), initiating early in development. Although XCI events are conserved in mouse and human postimplantation development, regulation of X-chromosome dosage in preimplantation development occurs differently. In preimplantation development, mouse embryos undergo imprinted form of XCI, yet humans lack imprinted XCI and instead regulate gene expression of both X chromosomes by dampening transcription. The long non-coding RNA Xist/XIST is expressed in mouse and human preimplantation and postimplantation development to orchestrate XCI, but its role in dampening is unclear. In this review, we discuss recent advances in our understanding of the role of Xist in X chromosome dosage compensation in mouse and human.
引用
收藏
页码：999 / 1013
页数：15
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