Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology

被引：99
|
作者：
Yan, Lina [1 ]
Shen, Jingjing [2 ]
Wang, Jinqiao [1 ]
Yang, Xiaoyan [1 ]
Dong, Shiyan [3 ]
Lu, Saijun [1 ]
机构：
[1] Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Rehabil Med, Wenling 317500, Zhejiang, Peoples R China
[2] Taizhou Univ, Sch Civil Engn & Architecture, Taizhou, Zhejiang, Peoples R China
[3] Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China
来源：
DOSE-RESPONSE | 2020年 / 18卷 / 03期
关键词：
chemotherapy; nanoparticle; drug delivery system; patient-friendly for oncology; PEGYLATED LIPOSOMAL DOXORUBICIN; IN-VIVO; TARGETED DELIVERY; CANCER-THERAPY; SOLID TUMORS; PHASE-I; ANTI-HER2; IMMUNOLIPOSOMES; CLINICAL-EVALUATION; FOLATE RECEPTOR; CASTOR-OIL;
D O I：
10.1177/1559325820936161
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, increase the killing effect of tumors, and reduce toxic and side effects. Currently, a variety of formulations based on nanoparticles (NPs) for delivering chemotherapeutic drugs have been put into clinical use, and several others are in the stage of development or clinical trials. In this review, after briefly introducing current cancer chemotherapeutic methods and their limitations, we describe the clinical applications and advantages and disadvantages of several different types of NPs-based chemotherapeutic agents. We have summarized a lot of information in tables and figures related to the delivery of chemotherapeutic drugs based on NPs and the design of NPs with active targeting capabilities.
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页数：12
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