The efficacy of ACCase inhibitors is usually reduced when tank-mixed with broad leaf herbicides. A greenhouse and afield experiments were carried out to determine the existence of antagonistic effects of clodinafop-propargyl associated with metsulfuron methyl or 2,4-D to control Italian ryegrass (Lolium multiflorum). In the greenhouse experiment, 21 treatments were tested, composed byclodynafop(0, 3, 6, 12. 24, 48 and 96 g ha(-1)) alone or tank-mixed with metsulfuron (2 and 4 g ha(-1)) or 2,4-D (470 g ha(-1)). In the field experiment, twelve treatments were set up in a factorial 6 x 2, composed by clodinafop (0, 3, 6, 12, 24, 48 and 96 g ha(-1)) alone or tank-mixed with metsulfuron (2 g ha(-1)). In the greenhouse experiment, the control (visual evaluation). 150 from the mixtures with metsulfuron (2 and 4 g ha(-1)) or 2,4-D (470 g ha(-1)) were 33, 84 and 151% higher than clodinafop applied atone. The I-50 from the rye live matter from the mixtures cited above were, respectively, 119, 244 and 72% higher than clodinafop applied alone. In the field experiment. rye live matter reduction was observed with increase of the levels of clodinafop applied alone, but rye live matter did not decrease, changing the levels of clodinafop tank-mixed with metsulfuron. The results reveal the antagonistic effect of tank-mixtures of clodinafop and metsulfuron or 2,4-D. We did make some considerations on the advantages of applying herbicides in more than one control operation, in comparison to graminicide and latifolicide mixtures.