Ultra-compact micro-photoacoustic tomography for brain imaging in vivo

被引:2
|
作者
Deng, Lijun [1 ,2 ]
He, Xingdao [3 ]
Zhang, Jian [4 ]
Liu, Guodong [2 ]
Han, Song [5 ]
Lou, Yimin [6 ]
Zeng, Lvming [1 ,2 ]
Ji, Xuanrong [1 ]
机构
[1] Guangdong Univ Technol, State Key Lab Precis Elect Mfg Technol & Equipmen, Guangzhou 510663, Peoples R China
[2] Jiangxi Sci & Technol Normal Univ, Key Lab Opt Elect & Commun, Nanchang 3300382, Jiangxi, Peoples R China
[3] Nanchang Hangkong Univ, Natl Engn Lab Destruct Testing & Optoelect Sensin, Nanchang 330063, Jiangxi, Peoples R China
[4] Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou 511436, Peoples R China
[5] Doppler Elect Technol Inc Co, Guangzhou 510530, Peoples R China
[6] Zhejiang Sci Tech Univ, Key Lab Opt Field Manipulat Zhejiang Prov, Hangzhou 310018, Peoples R China
基金
中国国家自然科学基金;
关键词
COMPUTED-TOMOGRAPHY; MOUSE-BRAIN;
D O I
10.1063/5.0076948
中图分类号
O59 [应用物理学];
学科分类号
摘要
In vivo wide-field brain microscopy has remained a non-trivial challenge in life science research, which would provide indispensable preclinical insight into the whole-brain metabolism and hemodynamic. Here, we developed an ultra-compact micro-photoacoustic tomography (mu PAT) system for fast brain imaging equipped with a 10 MHz 256-element full-ring ultrasound transducer array and 100 MS/s/ch multi-channel parallel data acquisition. The system design and calibration are presented in detail, along with the 62 mu m in-plane resolution comparable to the level of acoustic-resolution photoacoustic microscopy. The mu PAT system provided the ability to noninvasively use high-resolution mapping of the microvascular network of the full-view brain at different depths, cerebral ischemia, and intracerebral foreign-body. Ultra-compact mu PAT holds great potential to take the technology out of the lab for preclinical imaging and clinical translation.
引用
收藏
页数:6
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