Predictors of gait speed and its change over three years in community-dwelling older people

被引：19

作者：

Pinter, Daniela ^{[1
]}

Ritchie, Stuart J. ^{[2
,3
]}

Gattringer, Thomas ^{[1
]}

Bastin, Mark E. ^{[2
,4
,5
]}

Hernandez, Maria del C. Valdes ^{[4
,5
]}

Corley, Janie ^{[2
,3
]}

Maniega, Susana Munoz ^{[4
,5
]}

Pattie, Alison ^{[2
,3
]}

Dickie, David A. ^{[4
,5
]}

Gow, Alan J. ^{[2
,6
]}

Starr, John M. ^{[2
,7
]}

Deary, Ian J. ^{[2
,3
]}

Enzinger, Christian ^{[1
,8
]}

Fazekas, Franz ^{[1
]}

Wardlaw, Joanna ^{[2
,4
,5
,9
]}

机构：

[1] Med Univ Graz, Dept Neurol, A-8036 Graz, Austria

[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9YL, Midlothian, Scotland

[3] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9YL, Midlothian, Scotland

[4] Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[5] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH4 2XU, Midlothian, Scotland

[6] Heriot Watt Univ, Dept Psychol, Edinburgh EH14 4AS, Midlothian, Scotland

[7] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9YL, Midlothian, Scotland

[8] Med Univ Graz, Dept Radiol, Div Neuroradiol Vasc & Intervent Neuroradiol, A-8036 Graz, Austria

[9] Univ Edinburgh, UK Dementia Res Inst, Edinburgh EH8 9YL, Midlothian, Scotland

来源：

AGING-US | 2018年 / 10卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 奥地利科学基金会; 欧盟地平线“2020”; 英国医学研究理事会;

关键词：

gait; white matter hyperintensity volume; brain volume; grip strength; body mass index; aging; SMALL-VESSEL DISEASE; WHITE-MATTER ABNORMALITIES; PROGNOSTIC VALUE; BRAIN VOLUME; BALANCE; ADULTS; DISORDERS; DECLINE; AGE; CLASSIFICATION;

D O I：

10.18632/aging.101365

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We aimed to assess whether and how changes in brain volume and increases in white matter hyperintensity (WMH) volume over three years predict gait speed and its change independently of demographics, vascular risk factors and physical status. We analyzed 443 individuals from the Lothian Birth Cohort 1936, at mean age 73 and 76 years. Gait speed at age 76 was predicted by age, grip strength and body mass index at mean age 73, three-year brain volume decrease and WMH volume increase, explaining 26.1% of variance. Decline in gait speed to age 76 was predicted by the same five variables explaining 40.9% of variance. In both analyses, grip strength and body mass index explained the most variance. A clinically significant decline in gait speed (>= 0.1 m/s per year) occurred in 24.4%. These individuals had more structural brain changes. Brain volume and WMH changes were independent predictors of gait dysfunction and its three-year change, but the impact of malleable physical factors such as grip strength or body mass index was greater.

引用

页码：144 / 153

页数：10

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