Towards neuronal computing: Simple creation of two logic functions in 3D cell cultures using multi-electrode arrays

In this paper we begin by reviewing a number of previously presented approaches to control the electrical stimulation of in vitro neuronal networks for computation through the use of multi-electrode array technology. Drawing upon this research we describe how universal computation is possible with a form of three-dimensional cell culture so long as the underlying properties of the neuronal networks therein are considered. That is, we describe how it is possible to produce the Boolean logic functions NOT and OR in vitro in a simple way.