A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy

被引：96
|
作者：
Bernardes, Goncalo J. L. [1 ]
Casi, Giulio [2 ]
Truessel, Sabrina [1 ]
Hartmann, Isabelle [1 ]
Schwager, Kathrin [1 ,2 ]
Scheuermann, Joerg
Neri, Dario [1 ]
机构：
[1] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland
[2] Philochem AG, CH-8112 Otelfingen, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
angiogenesis; antibody-drug conjugates; cancer; cemadotin; drug delivery; ANTINEOPLASTIC AGENTS; TUMORS; FIBRONECTIN; DOMAIN; EXPRESSION;
D O I：
10.1002/anie.201106527
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Right on target: A chemically defined vascular-targeting antibody-drug conjugate (ADC) that offers comprehensive tumor coverage has been developed. When injected intravenously, this ADC potently inhibited tumor growth in a syngeneic immunocompetent model of murine cancer which cannot be cured by conventional cytotoxic agents. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：941 / 944
页数：4
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