Formulation and evaluation fast disintegrating film salbutamol sulfat using HPMC E15

The aim of the study was to formulate and evaluate Fast Disintegrating Film salbutamol sulfate with HPMC E15 polymer using a solvent casting method. FDF salbutamol sulphate preparations with variations oaaf HPMC E15 polymer concentration (F1 = 30%, F2 = 40%, F3 = 50% and F4 = 60%). Film of salbutamol sulphate was evaluated organoleptic, thickness, uniformity of weight, folding endurance, PH surface, moisture loss, moisture uptake and in vitro disintegration time. The result showed that film of salbutamol sulphate produce flexible and semi-transparent films. Evaluation results of thickness, weight, folding endurance, surface pH, moisture loss and moisture uptake and film disintegration time of all formulas met the requirements, except the uniformity of weight at F4, time of disintegration of F1, F2, F3 and F4 because high concentration of polymer and not added surfactant and superdisintegrant.