Microwave-assisted selenium dioxide oxidation of aryl methyl ketones to aryl glyoxals

被引：16
|
作者：
Young, Ryan M. [1 ]
Davies-Coleman, Michael T. [1 ]
机构：
[1] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 31期
基金：
新加坡国家研究基金会; 英国医学研究理事会;
关键词：
Microwave; Selenium dioxide; Oxidation; Aryl glyoxal; DERIVATIVES;
D O I：
10.1016/j.tetlet.2011.05.130
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report an improved procedure for the synthesis of phenyl glyoxal and a series of para-substituted aryl glyoxals by microwave-assisted selenium dioxide oxidation. The reaction time has been reduced from several hours to three minutes for activated aryl methyl ketone substrates and 18 min for deactivated substrates, with all reactions affording quantitative conversion into the corresponding aryl glyoxals. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4036 / 4038
页数：3
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