Revising antimalarial drug policy in Central America: experience in Panama

被引：14

作者：

Calzada, Jose E. ^{[1
]}

Samudio, Franklyn ^{[1
]}

Bayard, Vicente ^{[1
]}

Obaldia, Nicanor, III ^{[1
]}

de Mosca, Itza B. ^{[2
]}

Pascale, Juan M. ^{[1
]}

机构：

[1] ICGES, Panama City, Panama

[2] Minist Salud, Panama City, Panama

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 102卷 / 07期

关键词：

malaria; Plosmodium falciparum; antimalarials; drug resistance; Panama; Central America;

D O I：

10.1016/j.trstmh.2008.03.012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Panama is the first country in the Central American region that has officially discarded chloroquine as a first-tine drug to treat Plasmodium falciporum cases. Here we describe the clinical and molecular findings from autochthonous P. falciparum fatal cases, and the epidemiological situation that led to a change in the national antimalarial drug policy. Our results illustrate the potential pathogenicity of the strain of P. falciparum circulating in the country and provide molecular evidence of parasite resistance to chloroquine and antifolate drugs. The public health threats of these findings for the Central American region are discussed. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：694 / 698

页数：5

共 50 条

[1] FOOD AND DRUG LEGISLATION IN CENTRAL AMERICA AND PANAMA
OLSZYNAMARZYS, AE
[J]. FOOD DRUG COSMETIC LAW JOURNAL, 1968, 23 (05): : 253 - 259
[2] ESSENTIAL DRUG FORMULARIES IN CENTRAL-AMERICA AND PANAMA
LEE, D
QUINTERO, EG
LEROY, A
[J]. ACTA PHARMACOLOGICA ET TOXICOLOGICA, 1986, 59 : 199 - 199
[3] Short report:: Prevalence of Plasmodium falciparum mutations associated with antimalarial drug resistance during an epidemic in Kuna Yala, Panama, Central America
Samudio, F
Santamaría, AM
Obaldía, N
Pascale, JM
Bayard, V
Calzada, JE
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 73 (05): : 839 - 841
[4] Antimalarial natural products drug discovery in Panama
Calderon, Angela I.
Simithy-Williams, Johayra
Gupta, Mahabir P.
[J]. PHARMACEUTICAL BIOLOGY, 2012, 50 (01) : 61 - 71
[5] MANAGEMENT OF PLANT PARASITIC NEMATODES IN CENTRAL-AMERICA - THE PANAMA EXPERIENCE
PINOCHET, J
[J]. JOURNAL OF NEMATOLOGY, 1986, 18 (04) : 595 - 595
[6] MUSIC IN CENTRAL AMERICA AND PANAMA
CORDERO, R
[J]. JOURNAL OF INTERAMERICAN STUDIES AND WORLD AFFAIRS, 1966, 8 (03): : 411 - 418
[7] 4TH SEMINAR ON DRUG AND FOOD CONTROL FOR CENTRAL AMERICA AND PANAMA
不详
[J]. BOLETIN DE LA OFICINA SANITARIA PANAMERICANA, 1969, 66 (01): : 83 - &
[8] Antimalarial drug policy in Malawi
Brabin, BJ
Verhoeff, FH
Kazembe, P
Chimsuku, L
Broadhead, R
[J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1997, 91 : S113 - S115
[9] STUDIES ON CYSTICERCOSIS IN CENTRAL AMERICA + PANAMA
ACHA, PN
AGUILAR, FJ
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1964, 13 (1P1): : 48 - &
[10] Antimalarial drug combination policy: a caveat
Wongsrichanalai, C
Thimasarn, K
Sirichaisinthop, J
[J]. LANCET, 2000, 355 (9222): : 2245 - 2247

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